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KMID : 0603820110170010055
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Journal of Experimental & Biomedical Science
2011 Volume.17 No. 1 p.55 ~ p.60
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Preventive Effect of Natural Pigments Against Ultraviolet B-induced Cell Death in HaCat Cells
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Lim Jae-Chung
Bae Chun-Sik
Jeong Soo-Young
Boo Hee-Ock
Hwang Seong-Jin
Lim Seul-Ki
Park Min-Jung
Kim Jong-Chun
Kang Seong-Soo
Han Ho-Jae
Park Soo-Hyun
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Abstract
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Skin is a physical barrier against diverse injury and damages. Exposure to ultraviolet (UV) radiation causes detrimental skin injuries such as inflammation and cell death. The value of natural pigments could be applied to many usages including cosmetics. This study was conducted to examine the protective effect of natural pigments extracted from mulberry, balsam pear, purple-colored sweet potato, pehmannia root, gardenia fruit, and black rice against UV-induced cell death in HaCaT cells, human keratinocyte cell lines. In the present study, the exposure of 50 mJ/㎠ UV-B for 24 hr induced cell death in HaCaT cells, which was prevented by the pretreatment of extracts of mulberry, balsam pear, purple-colored sweet potato, rehmannia root, gardenia fruit, and black rice. In addition, the exposure of 50 mJ/㎠ UV-B for 24 hr also increased lipid peroxide (LPO) formation, compared to control in HaCaT cells, which was prevented by the pretreatment of extracts of mulberry, balsam pear, purple-colored sweet potato, rehmannia root, gardenia fruit, and black rice. In conclusion, the extracts of mulberry, balsam pear, purple-colored sweet potato, rehmannia root, gardenia fruit, and black rice prevented the UV-B-induced cell apoptosis via the inhibition of oxidative stress in HaCaT cells.
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KEYWORD
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Apoptosis, Keratinocytes, Natural pigments, Oxidative stress, Ultraviolet B
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